Mary and Child in the Catacombs Rome c. forth century
Epiphanius of Salamis (325-403 A.D.) from Palestine was a staunch defender of the divine truths during the Council of Nicaea. His writings about Mary are found in the Ancoratus (Anchor of Faith) and the Panarion (Basket of 80 heresies).
“Jesus is both man and God at once; mysterious for men, he who cannot be contained. As man, however, he is truly born of Mary having been begotten without manly seed.”
“Whoever honors the Lord also honors the holy vessel; who instead dishonors the holy vessel also dishonors his Master. Mary herself is that Holy Virgin, that is, the holy vessel.”
–Epiphanius of Salamis